Russian forces have hit a multi-storey apartment block in Kharkiv, Ukraine’s second-largest city, local officials say.
Regional governor Oleh Syniehubov said there had been two strikes on the city from guided bombs in a post on Telegram.
There was no word yet on casualties or damage.
Earlier, Ukraine’s foreign minister said he was concerned by intelligence suggesting nuclear facilities could be targeted before the winter.
Andrii Sybiha urged the UN’s nuclear watchdog and Ukraine’s allies to establish permanent monitoring missions at the country’s nuclear plants.
Russian forces launched three strikes on Friday on Kharkiv, with the city’s mayor Ihor Terekov writing on Telegram that two city districts had been hit.
Governor Synehubv said one strike occurred next to a hospital and a hotel.
Seven civilians, including three children, were hurt in the attacks, according to Mayor Terekhov, while 15 people were wounded by airstrikes earlier in the evening.
In Russia, multiple targets were hit by a massive Ukrainian drone attack on Saturday, with more than 100 drones launched at the country.
A fire tore through a Russian missile depot in the Tver region, the defence ministry in Moscow said.
Read more: Fire rips through Russian arms depot after huge Ukrainian drone attack
Footage shows a second Ukrainian drone attack on the southwestern Russian region of Krasnodar also triggered a fire and caused a series of explosions.
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Meanwhile, Ukraine’s President Volodymyr Zelenskky said he is preparing to meet Donald Trump in the coming week.
During his US trip, he plans to present President Biden with a so-called victory plan as he hopes to bring about an end to the conflict.